![]() ![]() ![]() Like other benzodiazepines, it produces a decrease in delta activity, though the effect of benzodiazepines on delta may not be mediated via benzodiazepine receptors. Midazolam is occasionally used as a hypnotic, especially in hospitals. In mice given chronic midazolam a slowly evolving tolerance developed to the anticonvulsant properties of midazolam over 15 days, although some anticonvulsant effects were still apparent after 15 days of continued administration. Long term use for the management of epilepsy is not recommended however, due to the significant risk of tolerance which renders midazolam and other benzodiazepines ineffective and as well the significant side effect of sedation. Midazolam is indicated for the acute management of aggressive or delirious patients and also is sometimes used for the acute management of seizures such as status epilepticus. Like other benzodiazepines, midazolam acts on benzodiazepine receptors which enhance the binding of GABA to the GABA A receptor which results in inhibitory effects on the central nervous system. ![]()
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